Hebbron, T., Bullock, S. and Cliff, D. (2008) NKalpha: Non-uniform epistatic interactions in an extended NK model. In: Artificial Life XI: Proceedings of the Eleventh International Conference on the Simulation and Synthesis of Living Systems, pp. 234-241, MIT Press, Cambridge, MA.
Download
![[img]](http://eprints.ecs.soton.ac.uk/style/images/fileicons/application_pdf.png)
| Accepted Version 801Kb | |
| Published Version 804Kb |
Abstract
Kauffman’s seminal NK model was introduced to relate the properties of fitness landscapes to the extent and nature of epistasis between genes. The original model considered genomes in which the fitness contribution of each of N genes was influenced by the value of K other genes located either at random or from the immediately neighbouring loci on the genome. Both schemes ensure that (on average) every gene is as influential as any other. More recently, the epistatic connectivity between genes in natural genomes has begun to be mapped. The topologies of these genetic networks are neither random nor regular, but exhibit interesting structural properties. The model presented here extends the NK model to consider epistatic network topologies derived from a preferential attachment scheme which tends to ensure that some genes are more influential than others. We explore the consequences of this topology for the properties of the associated fitness landscapes.
| Creators: | Tom Hebbron, Seth Bullock, Dave Cliff |
|---|---|
| Editors: | Seth Bullock, Jason Noble, Richard Watson, Mark A. Bedau |
| Item Type: | Book Section |
| Research Group: | Science and Engineering of Natural Systems |
| Deposited On: | 22 May 2008 16:32 by Hebbron, Thomas |
| ID Code: | 15781 |
| Last Modified: | 06 Jan 2010 15:56 |
| Performance Indicator: | EZ~03~02~04 |
Tools
Metadata
Download Statistics
Members of ECS may view the download statistics dashboard for this record.
Corrections
Repository Staff Only: item control page
